Ultrastructural, HistolÃ3gica!, and Biochemical Alterations Produced by 12-O-Tetradecanoyl-phorbol-13-acetate on Mouse Epidermis and Their Relevance to Skin Tumor Promotionl
نویسنده
چکیده
A single application of 12-0-tetradecanoyl-phorbol13-acetate to mouse skin induces an ordered sequence of ultrastructural changes in the cells of all layers of the epidermis, which correlate well with the changes in the rate of precursor incorporation into protein, RNA, and DNA in the whole skin and also with changes in the thickness, number of nucleated cell layers, and mitotic index of the interfollicular epidermis. The incorporation of orotic acid-5-3H into RNA is increased
منابع مشابه
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Topical application of retinole acid to mouse skin led to a dramatic inhibition of phorbol ester (12-O-tetradecanoylphorbol-13-acetate)-induced epidermal ornithine decarboxylase (EC 4.1.1.17) activity, an event proposed to be essen tial for tumor promotion. The degree of inhibition was de pendent on the dose and time of application of retinoic acid. In contrast, treatment with retinoic acid did...
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